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Effect of CYP2D6 genotype on flecainide pharmacokinetics in Japanese patients with supraventricular tachyarrhythmia

✍ Scribed by Kosuke Doki; Masato Homma; Keisuke Kuga; Kazutomi Kusano; Shigeyuki Watanabe; Iwao Yamaguchi; Yukinao Kohda


Publisher
Springer
Year
2006
Tongue
English
Weight
62 KB
Volume
63
Category
Article
ISSN
0031-6970

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✍ Tatsuhiko Yagihashi; Masafumi Mizuno; Bun Chino; Yuji Sato; Kei Sakuma; Toru Tak 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 121 KB

## Abstract ## Objective Risperidone is converted to 9‐hydroxyrisperidone by CYP2D6. Two parameters were used to examine the influences of CYP2D6 polymorphism and of co‐medication on risperidone metabolism: the risperidone:9‐hydroxyrisperidone concentration ratio (R:9‐OHR ratio) and the sum of the