Influence of Various Pharmaceutical Factors on Drug Release from Matrix Tablets
โ Scribed by V. A. Bykov; N. B. Demina; V. A. Kemenova; E. V. Velikaya; O. G. Chulyukov
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 458 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0091-150X
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Tablets were prepared from two slow-release formulations, both containing stearyl alcohol as a homogeneous insoluble matrix. The release of salicylic acid and of ephedrine was measured in oitro. It was found that the release profiles could be described by a nonlinear expression for both cylindrical
## Abstract A previously derived cubic equation describing the release of drugs from matrix tablets is compared with a more complex equation recently presented. Using data obtained from cylindrical hydrocortisone matrix tablets, it is shown that the simpler cubic equation affords an equally accepta