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Influence of shape factors on kinetics of drug release from matrix tablets II: Experimental

✍ Scribed by John Cobby; Michael Mayersohn; George C. Walker

Publisher: John Wiley and Sons
Year: 1974
Tongue: English
Weight: 593 KB
Volume: 63
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600630517

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✦ Synopsis

Tablets were prepared from two slow-release formulations, both containing stearyl alcohol as a homogeneous insoluble matrix. The release of salicylic acid and of ephedrine was measured in oitro. It was found that the release profiles could be described by a nonlinear expression for both cylindrical and biconvex tablets. Even though the rate of drug release varied noticeably with tablet shape, regression analysis of the release data indicated that the rate constants included in the expression did not vary significantly ( p = 0.05) with shape for tablets of the same overall composition.

Keyphrases o Tablets, slow release-release of salicylic acid and ephedrine from homogeneous insoluble matrix (stearyl alcohol), experimental relationship between release and tablet shape ibid., 55, 1224(1966).

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