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Influence of the Type of Surfactant and the Degree of Dispersion on the Lymphatic Transport of Halofantrine in Conscious Rats

✍ Scribed by Ditte M. Karpf; René Holm; Henning G. Kristensen; Anette Müllertz


Book ID
111603668
Publisher
Springer US
Year
2004
Tongue
English
Weight
92 KB
Volume
21
Category
Article
ISSN
0724-8741

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Postprandial administration of halofantrine (Hf), an important antimalarial, leads to 3-and 12-fold increases in oral bioavailability in humans and beagles, respectively, and corresponding 2.4-fold and 6.8-fold decreases in metabolic conversion to desbutylhalofantrine (Hfm). Factors contributing to