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Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats

โœ Scribed by Xin Yu Wang; Tatsuhiro Ishida; Masako Ichihara; Hiroshi Kiwada


Book ID
113690845
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
256 KB
Volume
104
Category
Article
ISSN
0168-3659

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The "accelerated blood clearance" (ABC) phenomenon describes a syndrome whereby the circulation time of a second dose of injected liposomes is substantially reduced, while the hepatic and splenic accumulations increase. To avoid this unexpected immune response, we have modified liposomes with cleava