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Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice

✍ Scribed by Tatsuhiro Ishida; Takako Ichikawa; Masako Ichihara; Yasuyuki Sadzuka; Hiroshi Kiwada


Book ID
113690482
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
221 KB
Volume
95
Category
Article
ISSN
0168-3659

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The "accelerated blood clearance" (ABC) phenomenon describes a syndrome whereby the circulation time of a second dose of injected liposomes is substantially reduced, while the hepatic and splenic accumulations increase. To avoid this unexpected immune response, we have modified liposomes with cleava