Influence of the Phenyl Side Chain on the Conformation of Cyclopropane Analogues of Phenylalanine
✍ Scribed by Alemán, Carlos; Jiménez, Ana I.; Cativiela, Carlos; Perez, Juan J.; Casanovas, Jordi
- Book ID
- 126418494
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 218 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0022-3654
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## Abstract Three phenylalanine derivatives, Ac‐Phe‐NHMe, H‐Phe‐NHMe, and Ac‐Phe‐OH, were selected as models of Phe residues situated at the internal, the N‐terminal, and the C‐terminal positions of peptide chains, respctively. The side‐chain conformations of the three compounds were analyzed from
In order to considerthe possibleinfluenceof the orientationof a side chain on the peptide backbone,we have studisd the molecularstructureof four %uCO-Pro-c3Pbe-NHMe modeldipeptides, where c3Phedenotes each of the four dimtereoisomeric2,3-methanopheny lahmines,by using IR and proton NMR experiment. A