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Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers

✍ Scribed by Ellen R Copson; Helen E White; Jeremy P Blaydes; David O Robinson; Peter W Johnson; Diana M Eccles


Book ID
115010970
Publisher
BioMed Central
Year
2006
Tongue
English
Weight
260 KB
Volume
6
Category
Article
ISSN
1471-2407

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## Abstract Germline mutations in the BRCA1 and BRCA2 genes are associated with a significantly increased lifetime risk for developing breast and/or ovarian cancer. However, incomplete penetrance and substantial variability in age of disease onset among carriers of the same mutation suggests the in