A randomized, four-way cross-over design was used to assess the disposition of the cardioprotective agent, dexrazoxane, in four male beagle dogs following single I.V. administration of 10, 25, 50, and 100mgkg-l doses. Parent drug was quantified in plasma and urine with a validated high-pressure liqu
Influence of the cardioprotective agent dexrazoxane on doxorubicin pharmacokinetics in the dog
โ Scribed by John R. Baldwin; Barbara A. Phillips; Stephen K. Overmyer; Naomi Z. Hatfield; Prem K. Narang
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 679 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The influence of ranitidine on the pharmacokinetics and toxicity of doxorubicin was studied in six female New Zealand white rabbits. Plasma pharmacokinetic data were first obtained from rabbits given 3 mg/kg doxorubicin. After 1 month, the same rabbits were treated with ranitidine, 2.5 mg/kg or 25 m
Ultrasound contrast agents (UCAs) are improving the signal-to-noise ratio of the reflected ultrasound so that Doppler frequency spectra can be recorded even under poor sonographic conditions. This is of particular diagnostic value in transcranial Doppler sonography. Dependhrg on speci6c pharmacologi
Doxorubicin is metabolized extensively to doxorubicinol by the ubiquitous aldoketoreductase enzymes. The extent of conversion to this alcohol metabolite is important since doxorubicinol may be the major contributor to cardiotoxicity. Aldoketoreductases are inhibited in vitro by phenytoin. The presen