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Pharmacokinetics in the rat and the dog of a nonionic nitroxide contrast agent for magnetic resonance imaging

✍ Scribed by Ulf G. Eriksson; Gabriele Schuhmann; Robert C. Brasch; Thomas N. Tozer


Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
909 KB
Volume
77
Category
Article
ISSN
0022-3549

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The introduction of a lipophilic moiety into the gadolinium chelate Gd-DTPA (dimeglumine gadopentetate, Magnevist) yielded Gd-EOB-DTPA (short form), which has potential as a magnetic resonance contrast agent for liver mass screening. The pharmacokinetics of Gd-EOB-DTPA in rats is nonlinear because a