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Influence of shared epitope–negative HLA–DRB1 alleles on genetic susceptibility to rheumatoid arthritis

✍ Scribed by Denis Reviron; Aleth Perdriger; Eric Toussirot; Daniel Wendling; Nathalie Balandraud; Sandrine Guis; Gilbert Semana; Pierre Tiberghien; Pierre Mercier; Jean Roudier


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
68 KB
Volume
44
Category
Article
ISSN
0004-3591

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Objective. To investigate whether interactions between tumor necrosis factor (TNF) microsatellite polymorphisms and the HLA-DRB1 shared epitope (SE) are associated with disease severity in rheumatoid arthritis (RA), and to determine if such associations are the same in male and female patients. Met