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Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA–DRB1 alleles encoding the shared epitope

✍ Scribed by Sampath Prahalad; Susan D. Thompson; Karen N. Conneely; Yunxuan Jiang; Traci Leong; Jennifer Prozonic; Milton R. Brown; Lori A. Ponder; Sheila T. Angeles-Han; Larry B. Vogler; Christine Kennedy; Carol A. Wallace; Carol A. Wise; Marilynn Punaro; Ann Reed; Jane L. Park; Elizabeth D. Mellins; Andrew S. Zeft; John F. Bohnsack; David N. Glass

Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 74 KB
Volume: 64
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.33376

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## Abstract ## Objective The shared epitope (SE)–containing HLA–DRB1 alleles represent the most significant genetic risk factor for rheumatoid arthritis (RA). Recent studies indicate that the SE alleles are associated with only RA that is characterized by the presence of anti–cyclic citrullinated