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Influence of several nucleotides on the competence development ofBacillus subtilis

✍ Scribed by M. T. Pérez Ureña; M. Espinosa; E. Garía; A. Portolés

Publisher
Springer
Year
1976
Tongue
English
Weight
387 KB
Volume
107
Category
Article
ISSN
0302-8933

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✦ Synopsis

The influence ofadenosine-3',5'-cyclic monophosphate (cAMP) and other nucleotides on the competence development of Bacillus subtilis was studied. The stimulation of competence which can be achieved by exposing physiologically low-competent cells to supernatants from highly competent cultures can be inhibited with different cAMP doses. When the same cells were suspended in a minimal medium with cAMP, varying degrees of stimulation of competence were observed depending on the time of addition of the drug. This effect is not specific for cAMP. It appears to be correlated to an increase of the amount of DNA bound to the competent cells, cAMP activities were antagonized by equimolar doses of adenosine-triphosphate (ATP) and guanosine-triphosphate (GTP).

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