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Influence of recipient and donor age in pediatric renal transplantation

Publisher
Springer
Year
1988
Tongue
English
Weight
385 KB
Volume
1
Category
Article
ISSN
0934-0874

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✦ Synopsis

The influence of recipient and donor age on the outcome of first cadaver kidney transplants was analyzed in a series of 1325 pediatric recipients and in 4230 transplants from pediatric kidney donors. Graft survival improved significantly with increasing recipient age (P<0.0001) and donor age (P< 0.0001). Combined analysis of recipient and donor age groups revealed an overriding effect of donor age on graft outcome. Kidneys from donors younger than 3 years old consistently yielded poor results regardless of recipient age. Kidneys from adult donors gave the best results even in young recipients 0-5 years of age. With adult donor kidneys in cyclosporin-treated patients, high 1-year graft survival rates of 86+9% (SE) in 15 0-to 5-year-old recipients, 85_+3% in 137 6-to 12-year-old recipients, and 83 + 1% in 6027 13-to 40-year-old recipients were observed.

πŸ“œ SIMILAR VOLUMES

Donor-recipient age differenceβ€”an indepe
Donor-recipient age differenceβ€”an independent risk factor in cyclosporin-treated renal transplant recipients
✍ Peter Donnelly; Peter Veitch; Peter Bell; Robin Henderson; Paul Oman; George Pro πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 455 KB

Whilst HLA matching is routine in renal transplantation the possible benefits of matching donor to recipient age have not been previously explored. The simultaneous effect on graft survival of donor and recipient age was therefore investigated for 274 consecutive first cadaver transplant recipients