Prevention of cytomegalovirus infection in the pediatric renal transplant recipient
โ Scribed by Patricia L. Hibberd; Robert H. Rubin
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 820 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0931-041X
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## Abstract Although most genes are highly conserved among strains of human cytomegalovirus (HCMV), several are unusually variable. By analyzing the sequence of two variable genes (__UL146__ and __UL74__) amplified directly from whole blood DNA extracts, multiple HCMV strains were detected in blood
The sources of cytomegalovirus (CMV) infection in seropositive renal transplant recipients include reactivation of latent endogenous virus in the recipient, reactivation of latent virus in donated kidney, or both. If infection occurs by either source, viruses isolated from the same recipient should
High dose oral acyclovir has been reported to be effective in preventing both cytomegalovirus (CMV) infection and disease in renal transplant recipients. We conducted a case-controlled study in which 42 cadaveric kidney transplant recipients were prophylactically treated with high dose oral acyclovi