Influence of pH on the precursors of phospholipid tubules in methanolic solution

✍ Scribed by Min-Hua Lu; Charles Rosenblatt; Paul Yager

• Book ID: 103037047
• Publisher: Elsevier Science
• Year: 1993
• Tongue: English
• Weight: 569 KB
• Volume: 65
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(93)90083-f

✦ Synopsis

Quasielastic light scattering measurements are reported for a 4 mg/ml solution of 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3phosphocholine in an 85:15 (by voi.) methanol/water mixture as a function of temperature and pH. We find that the tubule-liposome phase transition temperature is relatively insensitive to pH, whereas the transition from liposome to the high temperature clear phase varies strongly and nonmonotonically with temperature. The hydrodynamic radius of the liposome was measured as a function of pH, temperature and time after cooling from the clear phase. In addition, the average wall thickness of the liposomes is estimated from sedimentation data and found to be considerably greater than that of the tubule.