Influence of pentobarbital on some cardiovascular effects of cryptenamine in dogs

✍ Scribed by Bernard Korol

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 379 KB
• Volume: 60
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600600339

✦ Synopsis

In a series of 32 conscious and anesthetized paired dogs, pentobarbital anesthesia significantly lowered basal systolic/ diastolic arterial pressures, raised basal heart rate, and altered their responses to selected autonomimetic treatments. Pentobarbital anesthesia also significantly increased the effective hypo- tensive and/or bilateral carotid occlusion pressor response inhibiting dose of cryptenamine. Further examination of the data revealed that the conscious dog systolic depressor response to cryptenamine is the most sensitive and accurate bioassay criterion for the evaluation of cryptenamine potency. Keyphrases Pentobarbital-cryptenamine-cardiovascular effects dogs Cryptenamine-pentobarbital&cardiovascular effects, dogs Anesthesia, pentobarbital-influence on cryptenamine cardiovascular effects, dogs