Acute cardiovascular effects of bepridil in anesthetized mongrel dogs

✍ Scribed by Bhagavan S. Jandhyala; Marie L. Steenberg; Joseph P. Buckley

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 399 KB
• Volume: 3
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.430030509

✦ Synopsis

The cardiovascular effects of bepridil, a calcium antagonist, were investigated in pentobarbital-anesthetized dogs. The intravenous administration of bepridil, 5 mglkg, produced significant reductions in heart rate, cardiac output, and cardiac contractility. There was an initial transient marked increase in coronary blood flow and a significant increase in oxygen consumption which was followed by a decrease in oxygen consumption 5 min after administration of bepridil. The progressive and significant reductions in heart rate, cardiac contractility, cardiac output, and left ventricular minute work could be responsible for the secondary reduction in oxygen consumption. Coronary hemodynamic effects appeared to be independent of other cardiac effects since there appears to be no temporal correlation between these two phenomena. The coronary vasodilator property of bepridil was specific since there was an initial decrease in renal, femoral, and mesenteric blood flows.