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Influence of neuroleptics on the metabolism of tricyclic antidepressants—in vitro experiments with rat liver microsomes

✍ Scribed by Renate Krüger; Gaby Hölzl; Hans-Joachim kuss; Lore Schefold

Book ID
118317419
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
876 KB
Volume
21
Category
Article
ISSN
0006-3223

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Comparison of the metabolism of the three antidepressants amitriptyline, imipramine, and chlorimipramine in vitro in rat liver microsomes
✍ R. Krüger; G. Hölzl; H. J. Kuss; L. Schefold 📂 Article 📅 1986 🏛 Springer 🌐 English ⚖ 879 KB

The metabolism of the tricyclic antidepressants amitriptyline (AMI), imipramine (IMI), chlorimipramine (CMI) and some of their metabolites was studied in vitro in isolated liver microsomes of female Spraque-Dawley rats. Nine metabolites of AMI, seven metabolites of IMI, and 11 metabolites of CMI wer