Influence of loop sequence on relative stability of bimolecular triplex DNA
β Scribed by Linjing Yang; Imshik Lee; Chen Wang; Maozi Liu; Ming Su; Chunli Bai
- Book ID
- 105641038
- Publisher
- Science in China Press (SCP)
- Year
- 1998
- Tongue
- English
- Weight
- 377 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1674-7305
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Spectroscopic and calorimetric melting studies of 28 DNA hairpins were performed. These hairpins form by intramolecular folding of 16 base self-complementary DNA oligomer sequences. Sequence design dictated that the hairpin structures have a six base pair duplex linked by a four base loop and that t
## Abstract The triplex form of DNA is of interest because of a possible biological role as well as the potential therapeutic use of this structure. In this paper the stabilizing effects of two intercalating drugs, ethidium and the quinoxaline derivative 9βOHβB220, on DNA triplexes have been studie