Influence of infusion time on unchanged cisplatin disposition in patients with ovarian cancer
โ Scribed by Phillip A. Reece; Irene Stafford; Margaret Davy; Raymond Morris; Susan Freeman
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 540 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0344-5704
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๐ SIMILAR VOLUMES
Melphalan (L-PAM) pharmacokinetics were investigated in nine ovarian cancer patients before and after cisplatin (DDP) treatment. When L-PAM was given 24 h before DDP, the elimination half-life (t 1/2 beta), plasma clearance (Clp), and volume of distribution (Vd beta) of L-PAM were, respectively: 46.
The aim of the present study was to clarify the relationship between topoisomerase-I (topo-I) activity and sensitivity to second-line chemotherapy consisting of cisplatin and camptothecin-11 (CPT-11) in patients with ovarian cancer. Thirty Japanese women with relapsed epithelial ovarian cancer who r