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Influence of hydrophobic and steric effects in the acyl group on acylation of .alpha.-chymotrypsin by N-acylimidazoles

โœ Scribed by Kogan, Robert L.; Fife, Thomas H.

Book ID
126110932
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
609 KB
Volume
24
Category
Article
ISSN
0006-2960

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โœ Thomas H. Fife; Milton H. Werner ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 238 KB

The kinetic and mechanistic effects of substitution in the leaving group of N-acylimidazoles in อฐ-chymotrypsin-catalyzed hydrolysis reactions have been investigated. The values of k 2 /K m have been determined for acylation of the enzyme by a series of N-(3,3-dimethylbutyryl)-4(5)-substituted imidaz