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Effect of the leaving group in the hydrolysis of N-acylimidazoles. The hydroxide ion, water, and general-base catalyzed hydrolysis of N-acyl-4(5)-nitroimidazoles

โœ Scribed by Fife, Thomas H.; Natarajan, R.; Werner, Milton H.


Book ID
120502439
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
914 KB
Volume
52
Category
Article
ISSN
0022-3263

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๐Ÿ“œ SIMILAR VOLUMES


The Effect of the Leaving Group in the A
โœ Thomas H. Fife; Milton H. Werner ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 238 KB

The kinetic and mechanistic effects of substitution in the leaving group of N-acylimidazoles in อฐ-chymotrypsin-catalyzed hydrolysis reactions have been investigated. The values of k 2 /K m have been determined for acylation of the enzyme by a series of N-(3,3-dimethylbutyryl)-4(5)-substituted imidaz