## Abstract Normal human peripheral blood mononuclear leukocytes were induced to become cells that secrete rheumatoid factor after culture with aggregated IgG, but not monomeric IgG. A plaque‐forming cell assay was used to detect cells that secrete antibodies to IgG. Anti‐haptenated–sheep red cell
✦ LIBER ✦
Influence of human rheumatoid factor on numbers of antibody-producing cells
✍ Scribed by John C. Brown; Wallace V. Epstein
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 672 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
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Objective. To compare the B cell repertoire of normal individuals and patients with rheumatoid arthritis (RA) and, specifically, to identify precursor B cells with the potential to secrete rheumatoid factor (RF) and to understand the T helper cell requirements for the production of this autoantibody