The long-term oral ketoconazole (KTZ) treatment extensively inhibits hepatic CYP3A activity. We investigated the effect of the KTZ treatment on hepatic and intestinal extraction of nifedipine (NIF) using beagle dogs. Four dogs were given orally KTZ for 20 days (200 mg, bid). NIF was administered eit
β¦ LIBER β¦
Influence of first-pass effect on availability of drugs on oral administration
β Scribed by M. Gibaldi; R. N. Boyes; S. Feldman
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 353 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-3549
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