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Influence of exogenous interferon on the peripheral white blood cell count in mice

✍ Scribed by Miklos Degré

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
334 KB
Volume
14
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The effect of interferon (IF) injected intraperitoneally on the peripheral white blood‐cell (WBC) count in mice was studied. Mouse serum or brain IF produced in vivo in different mouse strains by injecting various viral inducers depressed the lymphocyte count from 3 to 24 h after the injection. The effect was correlated to the antiviral titer of the preparations. The inhibitory factor exhibited physico‐chemical properties of IF. Crude IF preparations obtained from mouse cell cultures, human IF and mock preparations devoid of anti‐viral activity exerted no lymphocytopenic effect.

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