## Abstract ## Objective Both type I interferons (IFNα and IFNβ) and type II IFN (IFNγ) signal via pSTAT‐1. Immunohistochemistry and the gene expression signatures of rheumatoid arthritis (RA) synovial tissue suggest an activated IFN/STAT‐1 signaling pathway. The aim of this study was to determine
✦ LIBER ✦
Activation of the interferon-γ signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells
✍ Scribed by Thomas Karonitsch; Eva Feierl; Carl Walter Steiner; Karolina Dalwigk; Adelheid Korb; Nikolaus Binder; Alfred Rapp; Günter Steiner; Clemens Scheinecker; Josef Smolen; Martin Aringer
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 283 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
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## Abstract ## Objective To construct a humanized mouse model of systemic lupus erythematosus (SLE) that resembles the human disease in order to define the pathophysiology and targets for treatments. ## Methods We infused peripheral blood mononuclear cells (PBMCs) from SLE patients into BALB‐ RA