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Influence of excluded volume upon macromolecular structure and associations in ‘crowded” media

✍ Scribed by Allen P Minton

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 591 KB
Volume: 8
Category: Article
ISSN: 0958-1669
DOI: 10.1016/s0958-1669(97)80159-0

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✦ Synopsis

Results of experimental studies published since the last major review of excluded volume effects in biopolymer solutions in 1993 add to our appreciation of the scope and magnitude of such effects. Recent theoretical studies have improved incrementally our ability to understand and model excluded volume effects in simple model systems.

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The concept of excluded volume and possible effects of excluded volume on the reactivity of macromolecules in highly volume-occupied or "crowded" media are introduced and briefly summarized. Theoretical and experimental studies of the effect of crowding on protein folding and unfolding, and on the e