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Influence of ethanol induction on the metabolic activation of genotoxic agents by isolated rat hepatocytes

✍ Scribed by J. M. Neis; B. W. J. Brömmelstroet; P. J. L. Gemert; H. M. J. Roelofs; P. Th. Henderson

Publisher
Springer-Verlag
Year
1985
Tongue
English
Weight
480 KB
Volume
57
Category
Article
ISSN
0340-5761

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Periportal (pp) and perivenous (pv) hepatocyte populations were separated using a two-directional closed perfusion technique with selective addition of collagenase either to direct or retrograde perfusions (Väänänen, H. et al., Liver 1983; 3:131). The activity of GPT in hepatocytes from the pp-area