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Influence of double infections on the induction of thymidine kinase by UV-irradiated herpes simplex virus types 1 and 2 and pseudorabies virus

✍ Scribed by S. Dundaroff; I. Just; D. Falke


Publisher
Springer Vienna
Year
1975
Tongue
English
Weight
744 KB
Volume
49
Category
Article
ISSN
1432-8798

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The enzyme herpes simplex virus type 1 thymidine kinase (HSV1 TK) salvages thymidine into the DNA metabolism of the virus. In the active site, the thymine ring of the nucleoside binds in a pocket, formed by two residues, Tyr-172 and Met-128, in a sandwich-type orientation. To investigate the nature