Neurovirulence of herpes simplex virus type 1 depends on age in mice and thymidine kinase expression
✍ Scribed by T. Ben-Hur; Julia Hadar; Y. Shtram; D. H. Gilden; Y. Becker
- Publisher
- Springer Vienna
- Year
- 1983
- Tongue
- English
- Weight
- 537 KB
- Volume
- 78
- Category
- Article
- ISSN
- 1432-8798
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## Abstract We previously isolated an acyclovir (ACV)‐resistant herpes simplex virus type 1 (HSV‐1), strain TAR, from a child with Wiskott‐Aldrich syndrome. An acyclovir‐sensitive HSV‐1, strain TAS, had been isolated from the same patient before the isolation of HSV‐1 TAR. The TK protein of ACV‐sen
## Abstract Isozyme analyses have been carried out to investigate the sites of integration of the herpes simplex type 2 (HSV‐2) thymidine kinase (TK) gene in biochemically transformed human [HeLa(BU25)/HSV‐2–6 Cl 4] cells. Extracts were prepared from He La (BU25)/HSV‐2–6 Cl 4 cells and from human—m