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Influence of Different Chemicals on MDR-1 P-Glycoprotein Expression and Activity in the HK-2 Proximal Tubular Cell Line

โœ Scribed by Nadia Romiti; Gianfranco Tramonti; Elisabetta Chieli


Book ID
112268629
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
227 KB
Volume
183
Category
Article
ISSN
0041-008X

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Expression of the MDR I (P-glycoprotein) gene confers resistance to several classes of chemotherapeutic drugs (multi-drug resistance). Colon carcinomas frequently express high levels of MDR I mRNA and P-glycoprotein, presumably reflecting the origin of these tumors from MDRl -expressing normal colon