Influence of chemical convulsants on kynurenic acid production in the rat brain
✍ Scribed by Kocki, Tomasz; Urbańska, Ewa M.; Wielosz, Marian; Turski, Waldemar A.
- Book ID
- 122292840
- Publisher
- Elsevier
- Year
- 2011
- Tongue
- English
- Weight
- 53 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1734-1140
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The anticonvulsant properties of the endogenous excitatory amino acid antagonist, kynurenic acid (KYA), were studied in prepubescent and adult rats using the amygdaloid kindling model of epilepsy. Treatment with intracerebroventricular KYA (360 nmoles (adult dose) or 240 nmoles (prepuhescent dose))
Kynurenic acid, a biologically active tryptophan metabolite, has been identified and measured in the rat brain and other organs using HPLC and GC/MS. Both the described methods required extraction of the compound in alkaline ethanol and initial purification on Dowex ion-exchange resins. The GC/MS ap