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Influence of anesthesia on brain distribution of [11C]methamphetamine in monkeys in positron emission tomography (PET) study

✍ Scribed by Michinao Mizugaki; Naoto Nakagawa; Hitoshi Nakamura; Takanori Hishinuma; Yoshihisa Tomioka; Shunji Ishiwata; Tatsuo Ido; Ren Iwata; Yoshihito Funaki; Masatoshi Itoh; Masato Higuchi; Nobuyuki Okamura; Takehiko Fujiwara; Mitsutomo Sato; Katsuhiro Shindo; Sumiko Yoshida


Book ID
113997316
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
107 KB
Volume
911
Category
Article
ISSN
0006-8993

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By means of positron emission tomography the uptake and kinetics of N-(methyl-11C)clozapine in different brain regions have been studied in Rhesus monkeys. 11C-clozapine rapidly entered the brain and maximum radioactive uptake was seen 5-12 min after administration. Highest uptake was measured in th