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Influence of 1,25-dihydroxyvitamin D3 on the plasma calcium and phosphate of the male newt,Cynops pyrrhogaster

✍ Scribed by Srivastav, Ajai K.; Sasayama, Yuichi; Suzuki, Nobuo; Srivastav, Sunil K.; Norman, Anthony W.

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
87 KB
Volume
284
Category
Article
ISSN
0022-104X

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✦ Synopsis

Male newts, Cynops pyrrhogaster, were injected daily intraperitoneally either with vehicle (50 Β΅l of 0.9% NaCl containing 0.1% ethanol/10 g body wt) or 1,25(OH) 2 D 3 (0.1 Β΅g/10 g body wt) for 10 days. The blood samples were collected on days 1, 3, 5, and 10 after initiation of the experiment, and plasma calcium and phosphate levels were analysed.

In 1,25(OH) 2 D 3 -injected newts there was a progressive hypercalcemia from day 1 to day 3. On day 5 and day 10 the levels were not significantly different from vehicle-injected newts. The plasma phosphate levels increased from day 3 to day 5. On day 10 the levels became almost normal.

To the best of our knowledge the present study is the first report from urodeles clearly indicating a true calcium and phosphate regulatory role of the vitamin D 3 endocrine system and 1,25(OH) 2 D 3 as a biologically active calcium and phosphate-regulating hormone in this group of vertebrates.

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