Effects of 1.28 nmol/kg doxercalciferol [1"(OH)D 2 ], a synthetic vitamin D 2 analog that undergoes metabolic activation to 1",25-dihydroxyvitamin D 2 , the naturally occurring, biologically active form of vitamin D 2 , on rat transporters and enzymes were compared with those of 1",25-dihydroxyvitam
Effects of 1α,25-dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo
✍ Scribed by Edwin C. Y. Chow; Huadong Sun; Ansar A. Khan; Geny M. M. Groothuis; K. Sandy Pang
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 812 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.694
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An intestinal perfusion technique is reported for the study of the differential absorption of vitamin D3 and its active metabolite, 1,25dihydroxyvitamin D3, through intact jejunal segments of rats. Samples of introduced and collected perfusates, intestinal homogenates, and portal blood were assayed
## Abstract The steroid hormone 1,25‐dihydroxyvitamin D~3~ [1,25(OH)~2~D~3~] rapidly stimulates the uptake of phosphate in isolated chick intestinal cells, while the steroid 24,25‐dihydroxyvitamin D~3~ [24,25(OH)~2~D~3~] inhibits the rapid stimulation by 1,25(OH)~2~D~3~. Earlier work in this labora