Influence and production of interferon in Rauscher virus infected mice
β Scribed by M. Vandeputte; J. De Lafonteyne; A. Billiau; P. De Somer
- Publisher
- Springer Vienna
- Year
- 1967
- Tongue
- English
- Weight
- 604 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1432-8798
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The protective effect of phenylhydrazine pretreatment seen in Rauscher leukemia virus-infected intact mice is not observed when splenectomized mice are used. Such mice succumb to infection even earlier than viral potency controls. Since phenylhydrazine is known to increase both splenic erythropoiesi
## Abstract Infection of BALB/c mice with Rauscher leukemia virus (RLV) gives rise to pronounced erythrocytopoiesis manifesting in splenomegaly and is associated with progressive development of anemia. In the spleen erythroid colony forming units (CFUβE) increase exponentially up to 800βfold that o