Inflammatory cerebrospinal fluid t cells have activation requirements characteristic of cd4+cd45ra- t cells
✍ Scribed by Michel Chofflon; Victor González; Howard L. Weiner; David A. Hafler
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 504 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0014-2980
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## Abstract Antigen‐independent adhesion of resting adult CD4^+^ CD45RO^+^ T cells to B lymphocytes has been shown to be transient and can be down‐regulated by CD4 major histocompatibility complex (MHC) class II molecule interactions. Conversely, adhesion of adult CD4+ CD45RA+ subpopulation to B ce
CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta