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Allorecognition of HLA-DR and -DQ transfectants by human CD45RA and CD45R0 CD4 T cells: Repertoire analysis and activation requirements

✍ Scribed by Matthias Merkenschlager; Hitoshi Ikeda; David Wilkinson; Peter C. L. Beverley; John Trowsdale; Amanda G. Fisher; Daniel M. Altmann


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
947 KB
Volume
21
Category
Article
ISSN
0014-2980

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## Abstract T cell activation requires costimulation of TCR/CD3 plus accessory receptors (__e.g.__ CD28). A hallmark of costimulation is the dynamic reorganization of the actin cytoskeleton, important for receptor polarization in the immunological synapse. The classical model of T cell costimulatio