nases. These results suggest that PTK, Ras, and PKC Hepatocyte growth factor (HGF) stimulated mitogenplay roles in MAP kinase activation induced by HGF and activated protein (MAP) kinases and MAP kinase kinase that MAP kinase activation resulting in AA release is in primary cultured rat hepatocytes.
Infectious inflammation of the CNS involves activation of mitogen-activated protein kinase and AKT proteins in CSF in humans
✍ Scribed by L. Pollak; T. Hanoch; M. J. Rabey; R. Seger
- Publisher
- Springer Milan
- Year
- 2005
- Tongue
- English
- Weight
- 82 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1590-1874
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Abbreviations: MAPK, mitogen-activated protein kinase; ERK, extracellular signalregulated kinase; HCC, hepatocellular carcinoma; T/N ratio, tumor (HCC) versus non-tumor (non-cancerous counterpart) ratio.
## Abstract 8‐Cl‐cAMP (8‐chloro‐cyclic AMP), which induces differentiation, growth inhibition and apoptosis in various cancer cells, has been investigated as a putative anti‐cancer drug. Although we reported that 8‐Cl‐cAMP induces growth inhibition via p38 mitogen‐activated protein kinase (MAPK) an
## Abstract ## BACKGROUND The mitogen‐activated protein kinase (MAPK) cascade is activated in response to various extracellular stimuli. The authors investigated the involvement of the p38 MAPK, a member of the MAPK superfamily, cascade in hepatoma cell lines and in human hepatocellular carcinoma