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Infection of natural killer cells by human herpesvirus 6

โœ Scribed by Lusso, Paolo; Malnati, Mauro S.; Garzino-Demo, Alfredo; Crowley, Richard W.; Long, Eric O.; Gallo, Robert C.

Book ID
109783753
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
685 KB
Volume
362
Category
Article
ISSN
0028-0836

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## Abstract Kaposi's sarcoma-associated herpesvirus (KSHV) establishes life-long infection by evading clearance by the host immune system. In de novo infection and lytic replication, KSHV escapes cytotoxic T cells and NK cells through downregulation of MHC class-I and ICAM-1 molecules and associate