Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations
✍ Scribed by Marta Epeldegui; Yee Ping Hung; Amy McQuay; Richard F. Ambinder; Otoniel Martínez-Maza
- Book ID
- 116755858
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 422 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0161-5890
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Two methods of cell sychronization, density-dependent arrest and double thymidine block, were used to assign two Epstein-Barr virus-associated antigens to different parts of the growth cycle of the human B lymphblastoid cell lines, WI-L2 and Raji. The Epstein-Barr nuclear antigen (EBNA), as detected
## Abstract Transformation to continuous cell lines has been studied in cultures of peripheral leukocytes from infectious mononucleosis (IM) patients and in co‐cultures of IM leukocytes and foetal cord blood leukocytes of opposite sex. The transformed cells in the co‐cultures were of mixed origin w