Infantile tuberous sclerosis changes in the brain: proton MR spectroscopy findings

✍ Scribed by R.N Sener

• Book ID: 104350717
• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 596 KB
• Volume: 24
• Category: Article
• ISSN: 0895-6111
• DOI: 10.1016/s0895-6111(99)00032-4

✦ Synopsis

A parietal hamartoma of a three-month-old boy with tuberous sclerosis was studied with magnetic resonance (MR) imaging, and proton MR spectroscopy. MR spectra were obtained with the single-voxel PRESS (point resolved spectroscopy; TR 1500 ms, TE 135 ms) sequence, in a 8 cc region of interest. Apparently low NAA/Cho (0.28), and NAA/Cr (0.37) ratios were noted in the hamartoma, that could suggest a neoplasm. The lesion and the surrounding brain tissue were studied again after seven months with spectroscopic imaging using the chemical shift sequence (TR 1500 ms, TE 40 ms). This study revealed apparently improved NAA/Cho (2.63), NAA/Cr (2.13) ratios in the hamartoma compared to the initial examination at three months of age, excluding the possibility of a neoplasm.