Cognition in multiple sclerosis: relevance of lesions, brain atrophy and proton MR spectroscopy
β Scribed by Antonio Giorgio; Nicola De Stefano
- Publisher
- Springer Milan
- Year
- 2010
- Tongue
- English
- Weight
- 127 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1590-1874
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## Abstract Magnetic resonance (MR) imaging and proton MR spectroscopy were performed in 14 patients with clinically definite multiple sclerosis (MS). Prominent resonances in the 0.5β2.0βppm region were seen in the spectra of six of nine gadopentetate dimeglumineβenhanced plaques in seven patients.
## Abstract Localized proton spectroscopy of the brain was performed on MS patients (__n__ = 18) and the results are compared with those of a control group (__n__ = 17). The experiments were performed in a 1.5βT Siemens Magnetom using the stimulated echo method and selective water suppression. Acqu
The effect of edema on metabolic changes in contrast-enhancing multiple sclerosis lesions was studied by combining quantification of proton MR spectra with segmentation of the volume-of-interest, which was based on biexponential T(2) relaxation. All lesions showed a second component (s(long)) with a
## Abstract Localized proton spectroscopy was performed in 15 patients with acute or chronic multiple sclerosis (MS). Some of the patients were investigated serially, being given a total of 22 spectroscopic investigations. Resonances corresponding to free lipids were observed in six plaques. This w