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Infantile Acute Monoblastic Leukemia with MLL Gene Rearrangements

✍ Scribed by Sachdev, Ritesh; Agarwal, Naveen; Khan, Mohd Ateek; Kumar, Anil

Book ID: 120959555
Publisher: Springer-Verlag
Year: 2012
Tongue: English
Weight: 295 KB
Volume: 31
Category: Article
ISSN: 0971-4502
DOI: 10.1007/s12288-012-0205-4

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Translocations of the MLL gene at chromosome band 11q23 are the most common cytogenetic alterations in de novo leukemia in infants and in leukemia related to chemotherapy with DNA topoisomerase II inhibitors. Experiments on knock-in mice suggest that additional mutational events may by required for