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Industrial Syntheses of the Central Core Molecules of HIV Protease Inhibitors

✍ Scribed by Izawa, Kunisuke; Onishi, Tomoyuki


Book ID
120242972
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
481 KB
Volume
106
Category
Article
ISSN
0009-2665

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✍ Stephan KΓΆnig; Ivar Ugi; Hans J. Schramm πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 583 KB

With the goal of obtaining inexpensive yet potent anti-AIDS drugs, simple inhibitors of HIV-1 protease were synthesised. The C2symmetrical pseudopeptidic substrate analogues can be prepared as inhibitors for HIV-1 protease starting from symmetrical ketones 3a-d by a facile four-step synthesis. After