Facile Syntheses of C2-Symmetrical HIV-1
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Stephan KΓΆnig; Ivar Ugi; Hans J. Schramm
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Article
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1995
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John Wiley and Sons
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English
β 583 KB
With the goal of obtaining inexpensive yet potent anti-AIDS drugs, simple inhibitors of HIV-1 protease were synthesised. The C2symmetrical pseudopeptidic substrate analogues can be prepared as inhibitors for HIV-1 protease starting from symmetrical ketones 3a-d by a facile four-step synthesis. After