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ChemInform Abstract: Facile Syntheses of C2-Symmetrical HIV-1 Protease Inhibitors.

✍ Scribed by S. KOENIG; I. UGI; H. J. SCHRAMM


Book ID
112028726
Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
27
Category
Article
ISSN
0931-7597

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Facile Syntheses of C2-Symmetrical HIV-1
✍ Stephan KΓΆnig; Ivar Ugi; Hans J. Schramm πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 583 KB

With the goal of obtaining inexpensive yet potent anti-AIDS drugs, simple inhibitors of HIV-1 protease were synthesised. The C2symmetrical pseudopeptidic substrate analogues can be prepared as inhibitors for HIV-1 protease starting from symmetrical ketones 3a-d by a facile four-step synthesis. After