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Induction of transplantation tolerance by intraportal injection of allogeneic bone marrow cells

✍ Scribed by Ahmed Eid; Shoshana Morecki; Shimon Slavin

Publisher
Springer
Year
1988
Tongue
English
Weight
383 KB
Volume
1
Category
Article
ISSN
0934-0874

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✦ Synopsis

Intraportal inoculation of C57BL/6 marrow cells into sublethally (400rad) irradiated BALB/c recipients resulted in durable chimerism and the permanent acceptance of C57BL/6 skin allografts. Sublethally irradiated recipients of a similar number of marrow cells inoculated systemically did not develop chimerism or any significant prolongation of the survival of C57BL/6 skin allografts. Consequently, lethal graft-versus-host disease developed only in recipients of intraportal marrow allografts (80%). The intraportal injection of allogeneic C57BL/6 marrow cells into nonirradiated recipients resulted in significant, although not permanent, prolongation of skin allograft survival without durable chimerism, suggesting that the introduction of alloantigens intraportally may favor the induction of nonresponsiveness to alloantigens even across strong major histocompatibility barriers. The relevance of these findings is discussed regarding the intraportal inoculation of allogeneic bone marrow cells for the treatment of genetic disorders in utero through the induction of neonatal tolerance.

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