Two adult patients with T cell acute lymphoblastic leukemia (ALL) received an intensive multiagent therapeutic regimen and failed to enter remission. Following cytoreduction with cyclophosphamide (60 mg/kg x 2) and total body irradiation (1000 rads) they underwent bone marrow transplantation. One pa
✦ LIBER ✦
Would suicide gene therapy solve the ‘T-cell dilemma’ of allogeneic bone marrow transplantation?
✍ Scribed by José L Cohen; Olivier Boyer; David Klatzmann
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 242 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0167-5699
No coin nor oath required. For personal study only.
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## CD134 (OX-40 ) is an activation-associated antigen which functions as a costimulatory receptor for CD4؉ T cells. In order to determine the expression of CD134 during immune recovery following allogeneic bone marrow transplantation (BMT), we measured its expression on T cells and T cell subsets