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Induction of thymidine−3h incorporation in multinucleated myotubes by rous sarcoma virus

✍ Scribed by H. H. Lee; M. E. Kaighn; J. D. Ebert

Book ID
102866470
Publisher
John Wiley and Sons
Year
1968
Tongue
French
Weight
839 KB
Volume
3
Category
Article
ISSN
0020-7136

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✦ Synopsis

During the diflhrentiation of skelotal muscle, mononucleated myoblasts fuse to form muhinucleated myotubes. Afier fusion, both DNA synthesis and nucl.ar division cease. When clones of chick onbryonic leg muscle consisting of both myoblasts and myotubes are infected with Rous sarcoma virus, DNA synthesis (as measured by thymidine-3H incorporation) is inhced in the nuclei of niyotiibes within 24 hours. On the other hand, nuclear division is not reactivated. These findings indicate that the restriction of D N A synthesis which attends the formation of myotubes is not irreversible since RSV, an R N A virus, reactivates D N A synthesis in niattrre myotrcbes.

Recently, it has been shown that two oncogenic DNA viruses, polyoma virus and Simian virus 40, stimulate cellular D N A synthesis in " contact inhibited " and X-irradiated cells (Dulbecco et

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